N Engl J Med. 1990 Aug 23;323(8):497-502.
A randomized, double-blind study of phenytoin for the prevention of post-traumatic seizures.
Temkin NR, Dikmen SS, Wilensky AJ, Keihm J, Chabal S, Winn HR.
RESULTS. Between drug loading and day 7, 3.6 percent of the patients assigned to phenytoin had seizures, as compared with 14.2 percent of patients assigned to placebo (P less than 0.001; risk ratio, 0.27; 95 percent confidence interval, 0.12 to 0.62). Between day 8 and the end of year 1, 21.5 percent of the phenytoin group and 15.7 percent of the placebo group had seizures; at the end of year 2, the rates were 27.5 percent and 21.1 percent, respectively (P greater than 0.2 for each comparison; risk ratio, 1.20; 95 percent confidence interval, 0.71 to 2.02).
